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The key factor behind acne formation is the male sex hormone androgen which is present in both male and female body. An enhanced amount of androgen activates and induces the amount of sebum secretion as well. And acne is the direct impact of augmented sebum of body oil which clogs up the skin pores in combination with dead skin cells, giving rise to comedones. Presence of skin-dwelling bacteria called Propionibacterium acnes play a vital part in entering and proliferating within the affected skin pores, raising the probability of inflammation. There might be several other sub-factors which play an important role in aggravating the above conditions. Anyone interested to clear up acne successfully must get aware of them. Wrong cleansing approach, insufficient water intake, indigestion, and irregular bowel clearance are some of these important factors which influence acne flare up.